Requirements for Renewal: Renewal of your license occurs every 2 years Registered Nurse (RN) licenses expire on February 28, May 31, or September 30 of odd years (2017, 2019). The expiration month depends on when your license was originally issued. All newly issued RN licenses expire on September 30 of odd years. 30 hours (3 hours related to substance abuse) and one of the following: 1,000 practice hours within the past 5 years, 400 practice hours within the past 2 years, Refresher course within the past 2 years